"Bob, Timing of the cylinder, ensures full rotation and lock-up before firing on all five chambers. In the case of a short hand, the cylinder will rotate but stop before lock occurs. In the case of a long hand, the cylinder fully rotates but will not lock-up, and the trigger will not engage. As you can imagine, if the chambers do not fully line up with the barrel when firing, you’ll be splitting the bullet. For liability reasons, we recommend the gun be sent back for the fitting of a cylinder to that specific gun. ~Ken"
So in other words, don't swap out cylinders.